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DEPArray Technology: Rare Cell Isolation


Silicon Biosystems has combined the ability to manipulate individual cells using DEP technology with high quality image-based cell selection to create the DEPArray™ System. This automated platform enables users to identify and recover specific individual cells of interest from complex, heterogeneous samples.

DEPArray™ technology is based on the ability of a non-uniform electric field to exert forces on neutral, polarizable particles, such as cells, that are suspended in a liquid. This electrokinetic principle, called dielectrophoresis (DEP), can be used to trap cells in DEP “cages” by creating an electric field above a subset of electrodes in an array that is in counter phase with the electric field of adjacent electrodes. When a DEP cage is moved by a change in the electric field pattern, the trapped cell moves with it.

For project consultation, please contact:
Teresa Alberobello, Ph.D.
Building 37, Room 3035

DEPArray™ Technology Applications

For many applications, the recovery of individual, viable rare cells or pure subpopulations of specific cells is critical for successful downstream analysis. 

Silicon Biosystems understands the challenges of isolating and working with single or rare cells and has developed products that make it practical for the molecular and cellular biology lab to achieve quality results, whatever the intended downstream application. 

The DEPArray™ platform and Ampli1™ genomic amplification kits enable automated identification, recovery and analysis of viable pure cells, allowing you to:

Input any sample type
Cells may be live or fixed, enriched, or from primary samples with small cell loads.

Recover any cell type
Any cells that can be identified using positive/negative selection of fluorescent markers or probes can be isolated on the DEPArray™ system. Morphological features, e.g. size or circularity, can be included in the cell selection criteria.

Analyze or culture recovered cells
Isolated cells remain intact and viable, enabling even the most sensitive and challenging downstream analyses to be performed, including mutational or transcriptional profiling.

The flexibility of the DEPArray™ system is enabling researchers around the world obtain results in a wide range of applications, including:

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